diff --git a/CMakeLists.txt b/CMakeLists.txt
index 48d43a84..d6fde749 100644
--- a/CMakeLists.txt
+++ b/CMakeLists.txt
@@ -337,17 +337,17 @@ target_link_libraries(lovr
 )
 
 if(LOVR_ENABLE_AUDIO)
-  target_compile_definitions(lovr PRIVATE LOVR_ENABLE_AUDIO)
   target_sources(lovr PRIVATE
     src/modules/audio/audio.c
     src/api/l_audio.c
     src/api/l_audio_source.c
     src/api/l_audio_microphone.c
   )
+else()
+  target_compile_definitions(lovr PRIVATE LOVR_DISABLE_AUDIO)
 endif()
 
 if(LOVR_ENABLE_DATA)
-  target_compile_definitions(lovr PRIVATE LOVR_ENABLE_DATA)
   target_sources(lovr PRIVATE
     src/modules/data/audioStream.c
     src/modules/data/blob.c
@@ -369,27 +369,30 @@ if(LOVR_ENABLE_DATA)
     src/lib/stb/stb_vorbis.c
     src/lib/jsmn/jsmn.c
   )
+else()
+  target_compile_definitions(lovr PRIVATE LOVR_DISABLE_DATA)
 endif()
 
 if(LOVR_ENABLE_EVENT)
-  target_compile_definitions(lovr PRIVATE LOVR_ENABLE_EVENT)
   target_sources(lovr PRIVATE
     src/modules/event/event.c
     src/api/l_event.c
   )
+else()
+  target_compile_definitions(lovr PRIVATE LOVR_DISABLE_EVENT)
 endif()
 
 if(LOVR_ENABLE_FILESYSTEM)
-  target_compile_definitions(lovr PRIVATE LOVR_ENABLE_FILESYSTEM)
   target_sources(lovr PRIVATE
     src/modules/filesystem/filesystem.c
     src/modules/filesystem/file.c
     src/api/l_filesystem.c
   )
+else()
+  target_compile_definitions(lovr PRIVATE LOVR_DISABLE_FILESYSTEM)
 endif()
 
 if(LOVR_ENABLE_GRAPHICS)
-  target_compile_definitions(lovr PRIVATE LOVR_ENABLE_GRAPHICS)
   target_sources(lovr PRIVATE
     src/modules/graphics/font.c
     src/modules/graphics/graphics.c
@@ -409,9 +412,10 @@ if(LOVR_ENABLE_GRAPHICS)
     src/lib/glad/glad.c
   )
 endif()
+  target_compile_definitions(lovr PRIVATE LOVR_DISABLE_GRAPHICS)
+endif()
 
 if(LOVR_ENABLE_HEADSET)
-  target_compile_definitions(lovr PRIVATE LOVR_ENABLE_HEADSET)
   target_sources(lovr PRIVATE
     src/api/l_headset.c
     src/modules/headset/headset.c
@@ -445,10 +449,11 @@ if(LOVR_ENABLE_HEADSET)
     target_compile_definitions(lovr PRIVATE LOVR_USE_DESKTOP_HEADSET)
     target_sources(lovr PRIVATE src/modules/headset/headset_desktop.c)
   endif()
+else()
+  target_compile_definitions(lovr PRIVATE LOVR_DISABLE_HEADSET)
 endif()
 
 if(LOVR_ENABLE_MATH)
-  target_compile_definitions(lovr PRIVATE LOVR_ENABLE_MATH)
   target_sources(lovr PRIVATE
     src/modules/math/math.c
     src/modules/math/curve.c
@@ -460,10 +465,11 @@ if(LOVR_ENABLE_MATH)
     src/api/l_math_vectors.c
     src/lib/noise1234/noise1234.c
   )
+else()
+  target_compile_definitions(lovr PRIVATE LOVR_DISABLE_MATH)
 endif()
 
 if(LOVR_ENABLE_PHYSICS)
-  target_compile_definitions(lovr PRIVATE LOVR_ENABLE_PHYSICS)
   target_sources(lovr PRIVATE
     src/modules/physics/physics.c
     src/api/l_physics.c
@@ -472,10 +478,11 @@ if(LOVR_ENABLE_PHYSICS)
     src/api/l_physics_shapes.c
     src/api/l_physics_world.c
   )
+else()
+  target_compile_definitions(lovr PRIVATE LOVR_DISABLE_PHYSICS)
 endif()
 
 if(LOVR_ENABLE_THREAD)
-  target_compile_definitions(lovr PRIVATE LOVR_ENABLE_THREAD)
   target_sources(lovr PRIVATE
     src/modules/thread/channel.c
     src/modules/thread/thread.c
@@ -484,11 +491,14 @@ if(LOVR_ENABLE_THREAD)
     src/api/l_thread_thread.c
     src/lib/tinycthread/tinycthread.c
   )
+else()
+  target_compile_definitions(lovr PRIVATE LOVR_DISABLE_THREAD)
 endif()
 
 if(LOVR_ENABLE_TIMER)
-  target_compile_definitions(lovr PRIVATE LOVR_ENABLE_TIMER)
   target_sources(lovr PRIVATE src/modules/timer/timer.c src/api/l_timer.c)
+else()
+  target_compile_definitions(lovr PRIVATE LOVR_DISABLE_TIMER)
 endif()
 
 # Resources
diff --git a/Tuprules.tup b/Tuprules.tup
index 43b81479..773d1714 100644
--- a/Tuprules.tup
+++ b/Tuprules.tup
@@ -59,16 +59,16 @@ EXTRAS_web = bin/lovr.js bin/lovr.wasm
 EXTRAS_@(THREAD)_web += bin/lovr.worker.js
 
 ## Modules
-CFLAGS_@(AUDIO) += -DLOVR_ENABLE_AUDIO
-CFLAGS_@(DATA) += -DLOVR_ENABLE_DATA
-CFLAGS_@(EVENT) += -DLOVR_ENABLE_EVENT
-CFLAGS_@(FILESYSTEM) += -DLOVR_ENABLE_FILESYSTEM
-CFLAGS_@(GRAPHICS) += -DLOVR_ENABLE_GRAPHICS
-CFLAGS_@(HEADSET) += -DLOVR_ENABLE_HEADSET
-CFLAGS_@(MATH) += -DLOVR_ENABLE_MATH
-CFLAGS_@(PHYSICS) += -DLOVR_ENABLE_PHYSICS
-CFLAGS_@(THREAD) += -DLOVR_ENABLE_THREAD
-CFLAGS_@(TIMER) += -DLOVR_ENABLE_TIMER
+DISABLE_@(AUDIO) += -DLOVR_DISABLE_AUDIO
+DISABLE_@(DATA) += -DLOVR_DISABLE_DATA
+DISABLE_@(EVENT) += -DLOVR_DISABLE_EVENT
+DISABLE_@(FILESYSTEM) += -DLOVR_DISABLE_FILESYSTEM
+DISABLE_@(GRAPHICS) += -DLOVR_DISABLE_GRAPHICS
+DISABLE_@(HEADSET) += -DLOVR_DISABLE_HEADSET
+DISABLE_@(MATH) += -DLOVR_DISABLE_MATH
+DISABLE_@(PHYSICS) += -DLOVR_DISABLE_PHYSICS
+DISABLE_@(THREAD) += -DLOVR_DISABLE_THREAD
+DISABLE_@(TIMER) += -DLOVR_DISABLE_TIMER
 
 ## Headset backends
 CFLAGS_@(SIMULATOR) += -DLOVR_USE_DESKTOP_HEADSET
@@ -271,13 +271,13 @@ LIBS += $(LIBS_y_web)
 SUFFIX = .html
 endif
 
-CFLAGS += $(FLAGS) $(FLAGS_y)
+CFLAGS += $(FLAGS) $(FLAGS_y) $(DISABLE_n) $(CFLAGS_y)
 LDFLAGS += $(FLAGS) $(FLAGS_y)
 CFLAGS += @(EXTRA_CFLAGS)
 LDFLAGS += @(EXTRA_LDFLAGS)
 
 ## Macros
-!cc = |> ^o CC %b^ $(CC) $(CFLAGS_y) $(CFLAGS) -o %o -c %f |>
+!cc = |> ^o CC %b^ $(CC) $(CFLAGS) -o %o -c %f |>
 !ld = |> ^ LD %o^ $(CC) -o %o %f $(LDFLAGS_y) $(LDFLAGS) |>
 !xd = |> ^ XD %f^ xxd -i %f > %o |>
 !cp = |> ^ CP %b^ cp %f %o |>
diff --git a/src/api/api.h b/src/api/api.h
index ca0e3c3d..11cb6d02 100644
--- a/src/api/api.h
+++ b/src/api/api.h
@@ -156,22 +156,22 @@ void luax_readcolor(lua_State* L, int index, struct Color* color);
 
 // Module helpers
 
-#ifdef LOVR_ENABLE_DATA
+#ifndef LOVR_DISABLE_DATA
 struct Blob;
 struct Blob* luax_readblob(lua_State* L, int index, const char* debug);
 #endif
 
-#ifdef LOVR_ENABLE_EVENT
+#ifndef LOVR_DISABLE_EVENT
 struct Variant;
 void luax_checkvariant(lua_State* L, int index, struct Variant* variant);
 int luax_pushvariant(lua_State* L, struct Variant* variant);
 #endif
 
-#ifdef LOVR_ENABLE_FILESYSTEM
+#ifndef LOVR_DISABLE_FILESYSTEM
 void* luax_readfile(const char* filename, size_t* bytesRead);
 #endif
 
-#ifdef LOVR_ENABLE_GRAPHICS
+#ifndef LOVR_DISABLE_GRAPHICS
 struct Attachment;
 struct Texture;
 struct Uniform;
@@ -180,7 +180,7 @@ int luax_optmipmap(lua_State* L, int index, struct Texture* texture);
 void luax_readattachments(lua_State* L, int index, struct Attachment* attachments, int* count);
 #endif
 
-#ifdef LOVR_ENABLE_MATH
+#ifndef LOVR_DISABLE_MATH
 #include "math/pool.h" // TODO
 float* luax_tovector(lua_State* L, int index, VectorType* type);
 float* luax_checkvector(lua_State* L, int index, VectorType type, const char* expected);
@@ -192,7 +192,7 @@ int luax_readmat4(lua_State* L, int index, float* m, int scaleComponents);
 uint64_t luax_checkrandomseed(lua_State* L, int index);
 #endif
 
-#ifdef LOVR_ENABLE_PHYSICS
+#ifndef LOVR_DISABLE_PHYSICS
 struct Joint;
 struct Shape;
 void luax_pushjoint(lua_State* L, struct Joint* joint);
diff --git a/src/api/l_event.c b/src/api/l_event.c
index 39df57a6..091fec0c 100644
--- a/src/api/l_event.c
+++ b/src/api/l_event.c
@@ -15,7 +15,7 @@ StringEntry lovrEventType[] = {
   [EVENT_KEYPRESSED] = ENTRY("keypressed"),
   [EVENT_KEYRELEASED] = ENTRY("keyreleased"),
   [EVENT_TEXTINPUT] = ENTRY("textinput"),
-#ifdef LOVR_ENABLE_THREAD
+#ifndef LOVR_DISABLE_THREAD
   [EVENT_THREAD_ERROR] = ENTRY("threaderror"),
 #endif
   { 0 }
@@ -220,7 +220,7 @@ static int nextEvent(lua_State* L) {
       lua_pushinteger(L, event.data.text.codepoint);
       return 3;
 
-#ifdef LOVR_ENABLE_THREAD
+#ifndef LOVR_DISABLE_THREAD
     case EVENT_THREAD_ERROR:
       luax_pushtype(L, Thread, event.data.thread.thread);
       lua_pushstring(L, event.data.thread.error);
diff --git a/src/api/l_lovr.c b/src/api/l_lovr.c
index aaafee99..2144c64e 100644
--- a/src/api/l_lovr.c
+++ b/src/api/l_lovr.c
@@ -4,34 +4,34 @@
 
 const luaL_Reg lovrModules[] = {
   { "lovr", luaopen_lovr },
-#ifdef LOVR_ENABLE_AUDIO
+#ifndef LOVR_DISABLE_AUDIO
   { "lovr.audio", luaopen_lovr_audio },
 #endif
-#ifdef LOVR_ENABLE_DATA
+#ifndef LOVR_DISABLE_DATA
   { "lovr.data", luaopen_lovr_data },
 #endif
-#ifdef LOVR_ENABLE_EVENT
+#ifndef LOVR_DISABLE_EVENT
   { "lovr.event", luaopen_lovr_event },
 #endif
-#ifdef LOVR_ENABLE_FILESYSTEM
+#ifndef LOVR_DISABLE_FILESYSTEM
   { "lovr.filesystem", luaopen_lovr_filesystem },
 #endif
-#ifdef LOVR_ENABLE_GRAPHICS
+#ifndef LOVR_DISABLE_GRAPHICS
   { "lovr.graphics", luaopen_lovr_graphics },
 #endif
-#ifdef LOVR_ENABLE_HEADSET
+#ifndef LOVR_DISABLE_HEADSET
   { "lovr.headset", luaopen_lovr_headset },
 #endif
-#ifdef LOVR_ENABLE_MATH
+#ifndef LOVR_DISABLE_MATH
   { "lovr.math", luaopen_lovr_math },
 #endif
-#ifdef LOVR_ENABLE_PHYSICS
+#ifndef LOVR_DISABLE_PHYSICS
   { "lovr.physics", luaopen_lovr_physics },
 #endif
-#ifdef LOVR_ENABLE_THREAD
+#ifndef LOVR_DISABLE_THREAD
   { "lovr.thread", luaopen_lovr_thread },
 #endif
-#ifdef LOVR_ENABLE_TIMER
+#ifndef LOVR_DISABLE_TIMER
   { "lovr.timer", luaopen_lovr_timer },
 #endif
   { NULL, NULL }
diff --git a/src/core/ref.h b/src/core/ref.h
index cd0c4477..10e56de5 100644
--- a/src/core/ref.h
+++ b/src/core/ref.h
@@ -7,7 +7,7 @@
 #define __has_builtin(x) 0
 #endif
 
-#ifndef LOVR_ENABLE_THREAD
+#ifdef LOVR_DISABLE_THREAD
 
 // Thread module is off, don't use atomics
 
@@ -39,7 +39,7 @@ static inline uint32_t ref_dec(Ref* ref) { return __atomic_sub_fetch(ref, 1, __A
 
 // stdatomic.h doesn't work in c++ (except on Android, where it is fine)
 #if !defined(__ANDROID__) && defined(__cplusplus)
-#error "The header core/ref.h cannot currently be included from C++ when threading is enabled with this compiler. Either remove your ref.h include from any C++ files, or rebuild LOVR with -DLOVR_ENABLE_THREAD=OFF"
+#error "The header core/ref.h cannot currently be included from C++ when threading is enabled with this compiler. Either remove your ref.h include from any C++ files, or rebuild LOVR with -DLOVR_DISABLE_THREAD=ON"
 #endif
 
 #include <stdatomic.h>
diff --git a/src/modules/event/event.c b/src/modules/event/event.c
index 8f678d70..83705a0e 100644
--- a/src/modules/event/event.c
+++ b/src/modules/event/event.c
@@ -53,7 +53,7 @@ void lovrEventDestroy() {
   for (size_t i = state.head; i < state.events.length; i++) {
     Event* event = &state.events.data[i];
     switch (event->type) {
-#if LOVR_ENABLE_THREAD
+#ifndef LOVR_DISABLE_THREAD
       case EVENT_THREAD_ERROR: lovrRelease(Thread, event->data.thread.thread); break;
 #endif
       case EVENT_CUSTOM:
@@ -75,7 +75,7 @@ void lovrEventPump() {
 }
 
 void lovrEventPush(Event event) {
-#ifdef LOVR_ENABLE_THREAD
+#ifndef LOVR_DISABLE_THREAD
   if (event.type == EVENT_THREAD_ERROR) {
     lovrRetain(event.data.thread.thread);
   }
diff --git a/src/modules/event/event.h b/src/modules/event/event.h
index 2e5b9e2d..16a42a23 100644
--- a/src/modules/event/event.h
+++ b/src/modules/event/event.h
@@ -16,7 +16,7 @@ typedef enum {
   EVENT_KEYRELEASED,
   EVENT_TEXTINPUT,
   EVENT_CUSTOM,
-#ifdef LOVR_ENABLE_THREAD
+#ifndef LOVR_DISABLE_THREAD
   EVENT_THREAD_ERROR,
 #endif
 } EventType;